Biomolecule Design

A currated reading + watch list for beginners to get started with RNA modelling and desing.

gRNAde is a geometric deep learning pipeline for 3D RNA inverse design, analogous to ProteinMPNN. gRNAde outperforms physically-based Rosetta and is significantly faster. (Invited book chapter for Methods in Molecular Biology)

Open-source benchmarking framework for evaluating and scaling up protein structure representation learning methods, comparing protein language models and Geometric GNNs trained on AlphaFoldDB, the largest non-redundant protein structure corpus.

We propose gRNAde, a geometric deep learning pipeline for 3D RNA inverse design from one or more backbone structures. (Invited book chapter for Methods in Molecular Biology)